Recent News

Tenofovir Side Effects: What You Need to Know

When you take tenofovir, a widely used antiviral drug for HIV and hepatitis B. Also known as TDF or TAF, it's one of the most common medications in HIV treatment plans because it stops the virus from multiplying. But like all strong drugs, it doesn’t come without trade-offs. Many people tolerate it well, but others face real, sometimes serious, side effects that can change how they live day to day.

The biggest concern with tenofovir, especially the older TDF version is its impact on kidney function, how well your kidneys filter waste from your blood. Studies show that long-term use can lead to reduced kidney filtration, protein in urine, or even kidney damage in a small but significant number of users. It’s not rare—it’s common enough that doctors now check kidney levels every 3 to 6 months if you’re on it. Another major issue is bone density loss, a slow, silent thinning of bones that increases fracture risk. This happens because tenofovir interferes with how your body handles phosphate, a mineral critical for strong bones.

Some users report nausea, diarrhea, or headaches early on, but those usually fade. The real red flags are persistent fatigue, swelling in feet or ankles, or unexplained muscle weakness—signs your body might be struggling. That’s why switching to the newer version, tenofovir alafenamide (TAF), a modified form with lower blood exposure and less kidney/bone impact, has become standard for many patients. TAF works just as well at fighting the virus but with fewer side effects. Still, it’s not magic—it can still affect weight, cholesterol, and liver enzymes in some.

If you’re on tenofovir, you’re not alone. Millions rely on it, and many manage it safely. But knowing what to watch for makes all the difference. You should understand how it interacts with other meds, why regular blood tests matter, and when it’s time to consider alternatives like emtricitabine/tenofovir, a combo pill that includes tenofovir but is often paired with other drugs, or even newer agents like bictegravir or dolutegravir. This collection of posts dives into real patient experiences, clinical comparisons, and practical advice on managing these side effects—whether you’re just starting treatment or have been on it for years.

Tenofovir for Adolescents: What Parents and Caregivers Need to Know

Tenofovir for Adolescents: What Parents and Caregivers Need to Know

A clear guide for parents and caregivers on tenofovir use in adolescents, covering how it works, side effects, adherence tips, PrEP vs treatment, and long-term care for teens with HIV or at risk.

read more